Effectivity and safety of oxycodone plus acetaminophen for postoperative acute pain relief：a Meta-analysis
10.3969/j.issn.1671-8348.2015.30.022
- VernacularTitle:羟考酮／对乙酰氨基酚组合药物缓解术后急性疼痛有效性和安全性的 Meta分析
- Author:
Jingping XIAO
;
Guojun WANG
;
Hengli LUO
;
Ting YANG
;
Gongli HU
- Publication Type:Journal Article
- Keywords:
oxycodone;
acetaminophen;
postoperative pain;
systematic review
- From:
Chongqing Medicine
2015;(30):4239-4243
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effectivity and safety of oxycodone plus acetaminophen for postoperative acute pain re‐lief .Methods Randomized controlled trials (RCT ) on combination of oxycodone plus acetaminophen treating postoperative pain re‐lief were searched from the following data‐bases as PubMed ,EMbase ,MEDLINE(Ovid) ,the Cochrane Library ,CNKI and WAN‐FANG from the date of their establishment to September 2014 .The data of RCT meeting the inclusive criteria were extracted ac‐cording to Cochrane methods by two reviewers independently ,and after the quality was evaluated and cross checked ,meta analyses were conducted using RevMan 5 .2 sotware .Results A total of 18 studies involving 2 213 patients were included .The results of Meta‐analyses showed that compared with placebo group or the equal dosage oxycodone alone group ,the combinations of oxycodone plus acetaminophen were more effective in postoperative pain relief (P<0 .01) .However ,there are no significant difference in the effective between the combinations of oxycodone plus acetaminophen and the higher dosage oxycodone alone group or the acetamin‐ophen alone group for postoperative pain relief (P>0 .05) .Adverse events occurred more frequently with combination therapy than placebo or acetaminophen alone group ,but were generally described as mild to moderate in severity and rarely led to withdrawal . There are no significant difference in the adverse events between the combination of oxycodone plus acetaminophen and the oxyc‐odone alone group .Conclusion The present study showed that combination of oxycodone plus acetaminophen is effective and high safe in postoperative acute pain relief .
