The role of hypothalamocerebellar histaminergic projections in somatic-visceral integration of rats
10.3969/j.issn.1671-8348.2015.28.006
- VernacularTitle:下丘脑-小脑神经通路在大鼠躯体-内脏反应整合中的作用
- Author:
Yecheng HE
;
Dongyin LI
;
Yi ZHANG
- Publication Type:Journal Article
- Keywords:
histamine;
hypothalamocerebellar histaminergic projections;
somatic-visceral integration
- From:
Chongqing Medicine
2015;(28):3915-3917
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the role of hypothalamocerebellar histaminergic projections in somatic‐visceral integration of rats .Methods A total of 120 SD rats were randomly divided to 6 groups :group A - F ;which separately microinjected saline (group A) ,triprolidine(selective antagonist of H1 receptor ,group B) ,2‐PyEA(selective agonist of H1 receptor ,group C) ,ranitidine (selective antagonist of H2 receptor ,group D) ,dimaprit (selective agonist of H2 receptor ,group E) and histamine (group F) to the deep nuclei of rats .The abilities of rats somatic‐visceral integration were observed when hypothalamocerebellar histaminergic pro‐jections were obstructed or enhanced compared to group A .Results The somatic‐visceral integration of rats were obstructed obvi‐ously in group D and enhanced in group E & group F compared to group A ,while group B and group C had no differences compared to group A .Conclusion Hypothalamocerebellar histaminergic projections play a key role in somatic‐visceral integration through the way of H2 receptors .
