Analgesic scheme and safety after total knee arthroplasty
10.3969/j.issn.2095-4344.2015.39.005
- VernacularTitle:膝关节置换后镇痛方案的选择与安全性评价
- Author:
Rongguo WANG
;
Dunyi QI
- Publication Type:Journal Article
- Keywords:
Tissue Engineering;
Knee Joint;
Analgesia
- From:
Chinese Journal of Tissue Engineering Research
2015;(39):6256-6261
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Positive total knee replacement surgery greatly improved the quality of life in patients with knee joint degenerative disease, but widespread perioperative acute pain increases the probability of complications and hinders the rehabilitation exercises of patients; therefore perioperative pain processing has become an important topic of the current knee replacement.
OBJECTIVE:To compare the efficacy and safety of preemptive analgesia of parecoxib sodium, periarticular analgesia and their combination in the total knee arthroplasty, and explore reasonable and effective analgesic scheme.
METHODS:60 patients undergoing knee replacement were randomly selected in Xuzhou Central Hospital from May 2012 to December 2014, and then they were divided with a random number table into four groups: preemptive analgesia with parecoxib sodium, periarticular analgesia, combination and blank control, with 15 cases in each group. Different programs were used in each group during total knee arthroplasty.
RESULTS AND CONCLUSION:At 6, 12, 24 and 36 hours after operation, rest pain scores, activity pain scores and drug dose were significantly lower in the combination group than other three groups (P < 0.05). Time interval of anesthetic use was significantly longer in the combination group than other three groups (P < 0.05). At 3 days after replacement, active leg-raising time and active genuflex 90° time were significantly shorter in the combination group than other three groups (P < 0.05), and range of motion of the knee was good. The incidence of adverse reaction was lowest in the combination group (P < 0.05). These results indicate that preemptive analgesia of parecoxib sodium combined with periarticular analgesia is a safe and effective analgesic option, can obviously reduce pain after replacement, the amount of anesthetics and adverse reactions, improve range of motion of the knee and promote early rehabilitation of patients.
