Meta analysis of association between XRCC1 Arg399Gln and nasopharyngeal carcinoma susceptibility
10.3969/j.issn.1671-8348.2015.28.022
- VernacularTitle:XRCC1 Arg399Gln 基因多态性与鼻咽癌易感性的 Meta 分析
- Author:
Xiaohong WU
;
Xiangyuan YU
;
Chengqiang WANG
- Publication Type:Journal Article
- Keywords:
X-ray cross-complementing group 1;
polymorphism,single nucleotide;
nasopharyngeal neoplasms;
Meta analysis
- From:
Chongqing Medicine
2015;(28):3962-3965
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between SNP 399 in X‐ray cross‐complementing group 1 (XRCC1) and na‐sopharyngeal carcinoma susceptibility .Methods The case‐control studies on the association between SNP 399 in XRCC1 (X‐ray cross‐complementing group 1) and nasopharyngeal carcinoma susceptibility were collected by CBM disc and Pubmed .Various re‐search and statistical analysis were used by Stata12 .0 and Review Manager 5 .0 software .Taking the fixed effects model or random effects model to merge OR values and corresponding 95% confidence intervals to assess Arg399Gln polymorphism and genetic sus‐ceptibility to nasopharyngeal .Results Compared 399Gln with 399Arg allele ,combined OR and 95% CI were 1 .14 (1 .04 - 1 .26) respectively ,and the results of heterogeneity test was I2 = 32% ,PHet = 0 .18 .Under the recessive and co‐dominant models ,combined OR and 95% CI were 1 .30(1 .04 - 1 .63) and 1 .37(1 .09 - 1 .72) respectively ,and with no significant heterogeneity was observed (I2 = 0 ,PHet = 1 .00) and (I2 = 0 ,PHet = 0 .96) .Conclusion XRCC1 gene Arg399Gln polymorphism is closely related to the genetic susceptibility of NPC ,399Gln allele may be a risk of genetic factors in NPC incidence in asians .
