Analysis on iron metabolism indicators in children with various genotypes of thalassemia
10.3969/j.issn.1673-4130.2015.20.011
- VernacularTitle:不同基因型珠蛋白生成障碍性贫血患儿血清铁代谢指标分析
- Author:
Weiyi XIA
;
Rong TAN
;
Xi QIN
- Publication Type:Journal Article
- Keywords:
thalassemia;
serum iron;
total iron blinding capacity;
transferrin
- From:
International Journal of Laboratory Medicine
2015;(20):2947-2949
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the value of iron metabolism indicatorsin thalassemia .Methods 218 cases of thalassemia ,57 ca‐ses of iron deficiency anemia (IDA) children and 70 healthy children(control group) were enrolled in the study ,and serum iron (SI) ,total iron binding capacity(TIBC) ,transferrin(Tf) ,serum ferritin (SF) were detected for them .Results β‐thalassemia double heterozygous(β0 ) or homozygous group :SI levels were significantly higher than the other groups(P<0 .05) ,while TIBC ,Tf levels were significantly lower than the other groups(P<0 .05);α‐thalassemia group (static α‐thalassemia ,standard α‐thalassemia):SI , TIBC levels compared with control group showed no significant difference(P>0 .05) ,but Tf level was higher than control group(P<0 .05);hemoglobin H disease group:when TIBC ,Tf levels compared with the control group ,the difference was statistically signif‐icant(P<0 .05) ,when SI compared with the control group ,the difference was not statistically significant(P>0 .05) .Conclusion Compared with Tf ,SI and TIBC are better indicators for monitoring iron loading in children with thalassemia .The increased SI level and decreased TIBC level are two indicators for the diagnosis of β0 thalassemia in children with cellule anaemia .
