Comparison of oxycodone and dezocine for prevention of fentanyl-induced cough during anesthesia induction
10.3760/cma.j.issn.0254-1416.2015.07.003
- VernacularTitle:羟考酮与地佐辛预防麻醉诱导时芬太尼诱发咳嗽反应效果的比较
- Author:
Meihua HUANG
;
Hui WANG
;
Jin XU
;
Ping LI
- Publication Type:Journal Article
- Keywords:
Oxycodone;
Fentanyl;
Cough;
Dezocine
- From:
Chinese Journal of Anesthesiology
2015;35(7):787-789
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare oxycodone and dezocine for prevention of fentanyl-induced cough during induction of anesthesia.Methods One hundred fifty patients of both sexes, aged 25-60 yr, weighing 45-75 kg, of ASA physical status Ⅰ or Ⅱ , scheduled for elective surgery under general anesthesia, were randomly divided into 3 groups (n =50 each) using a random number table: dezocine group (group Dez), oxycodone group (group Oxy), and normal saline control group (group NS).In group Dez, dezocine 0.1 mg/kg (in 10 ml of normal saline) was injected intravenously, and 5 min later fentanyl 3 μg/kg was injected over 5 s.In group Oxy, oxycodone 0.1 mg/kg (in 10 ml of normal saline) was injected intravenously, and 5 min later fentanyl 3 μg/kg was injected over 5 s.In group NS, normal saline 10 ml was injected intravenously, and 5 min later fentanyl 3 μg/kg was injected over 5 s.The occurrence and degree of cough were observed within 2 min after administration of fentanyl.Results The incidence of cough was 2％, 4％ and 30％ in Oxy, Dez and NS groups, respectively.Compared with group NS, the incidence of cough was significantly decreased, and the degree of cough was mitigated in Oxy and Dez groups.There was no significant difference in the incidence and degree of cough between Dez group and Oxy group.Conclusion Both intravenous oxycodone and dezocine 0.1 mg/kg can significantly prevent fentanyl-induced cough during induction of anesthesia with similar efficacy.
