The damage of infectious burden on cognition and its related mechanisms
10.3760/cma.j.issn.1674-6554.2015.10.026
- VernacularTitle:感染负荷对认知功能的损害作用及机制
- Author:
Yan LIANG
;
Junjian ZHANG
- Publication Type:Journal Article
- Keywords:
Infectious burden;
Cognition;
Inflammation
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2015;24(10):953-956
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the damaging effect of infectious burden on cognition and the potential mechanisms, and reveal a newly insight into the prevention and treatment of cognitive impairment.Methods Based on the PUBMED, CBM and CNKI database, the articles involving the definition of infectious burden and the relationship between infectious burden and cognition were searched with the main key words infectious burden , cognition and inflammation.Results This study finally included 42 articles from the primarily retrieved 342 articles.Overall, the definition of infectious burden remains controversial.Infectious burden was related to cognitive impairment whereas the potential mechanisms had not been fully elucidated.Conclusion Infectious burden is the risk factor of cognitive impairment via the possible mechanisms of inflammation,vascular lesion and neuronal toxicity.
