Association between KCNJ11 polymorphism and essential hypertension in Xinjiang Kazak population
10.7652/jdyxb201506015
- VernacularTitle:KCNJ11基因多态性与新疆哈萨克族原发性高血压的相关性
- Author:
Lijie WANG
;
Wenwen ZHANG
;
Ketao MA
;
Li LI
;
Junqiang SI
- Publication Type:Journal Article
- Keywords:
hypertension;
KCNJ1 1;
Kazak;
single-nucleotide polymorphism
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2015;(6):792-795
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the single nucleotide polymorphism (SNP)of KCNJ1 1 (inwardly rectifying potassium channel,subfamily J,member 1 1)gene and essential hypertension (EH)in Xinjiang Kazak population.Methods The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP ) method was used to detect genotypes of rs2285676 polymorphism of KCNJ1 1, including 126 hypertensives (EH group)and 126 normotensives (NT group)in Xinjiang Kazak population.Multiple-factor unconditional Logistic regression analysis was used to evaluate the risk factors for hypertension in Xinjiang Kazak. Results Logistic regression analysis showed that KCNJ1 1-rs2285676 genotypes,sex,weight,total cholesterol and triglyceride were not associated with hypertension;body mass index (BMI)and high-density lipoprotein (HDL) were protective factors affecting hypertension while low-density lipoprotein (LDL ) was a risk factor for hypertension.Genotypes (TT,CT and CC)and allele frequencies (T and C)of the SNP of rs2285676 in KCNJ1 1 gene were 50.00%,48.41%,1.59%,74.21% and 25.79% in EH group,respectively.The differences between EH and normal control were not significant (P >0.05).Conclusion The rs2285676 polymorphism of KCNJ1 1 is not associated with EH in Xinjiang Kazak population.
