The significance of cerebrospinal fluid lactate dehydrogenase measurement in patients with central nervous system diseases
10.3969/j.issn.1673-4130.2015.20.032
- VernacularTitle:脑脊液乳酸脱氢酶测定在中枢神经系统疾病中的意义
- Author:
Qiuju WANG
;
Xianming LIANG
;
Xingxing LU
- Publication Type:Journal Article
- Keywords:
lactate dehydrogenase;
leukemia;
lymphoma;
brain neoplasms;
meningitis;
cerebrospinal fluid
- From:
International Journal of Laboratory Medicine
2015;(20):2997-2999
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the levels of LDH in cerebrospinal fluid in patients with different types of central nervous sys‐tem diseases .Methods Cerebrospinal fluid LDH were detected by rate assay in control group and disease group(including patients with acute leukemia ,lymphoma ,brain neoplasms and meningitis) .Results In ptients with acute leukemia ,the cerebrospinal fluid LDH level of central nervous system leukemia(CNSL) group was (28 .68 ± 9 .29)U/L ,which was higher than that of non CNSL group ,and the difference were significance(P<0 .05) .In lymphoma patients ,cerebrospinal fluid LDH level of brain metastasis pa‐tients was (125 .20 ± 115 .24)U/L ,which was higher than that of lymphoma patients without brain metastasis ,the difference was significant(P<0 .05) .In patients with brain neoplasms ,cerebrospinal fluid LDH level of meningeal carcinomatosis group was (77 . 37 ± 128 .15)U/L ,which was higher than that of primary brain neoplasms group ,the difference was significant(P<0 .05) .In pa‐tients with meningitis ,cerebrospinal fluid LDH level of tuberculous meningitis group and purulent meningitis group patients were (54 .48 ± 84 .60U/L) and (43 .54 ± 32 .05)U/L respectively ,which were higher than those of viral meningitis group patients ,and the differences were significant (P<0 .05) .Conclusion LDH in cerebrospinal fluid can be used in early diagnosis of CNSL ,brain metastsisly of mphoma ,meningeal carcinomatosis and differential diagnosis of meningitis .
