Role of transcription factor DEC1 in the initiation and progression of malignant tumors
10.11665/j.issn.1000-5048.20150504
- VernacularTitle:转录因子 DEC1在肿瘤发生发展过程中的作用
- Author:
Huan YANG
;
Jing XIONG
;
Wenjing LUO
;
Tao XI
- Publication Type:Journal Article
- Keywords:
transcription factor;
DEC1;
proliferation;
apoptosis;
invasion and metastasis;
cellular senescence
- From:
Journal of China Pharmaceutical University
2015;(5):541-547
- CountryChina
- Language:Chinese
-
Abstract:
DEC1 is a basic helix-loop-helix(bHLH)transcription factor involved in the regulation of cell prolif-eration;cell differentiation;lymphocytes maturation;circadian rhythms;immune response and response to hypoxia.Recent studies have revealed that the expression of DEC1 is abnormally high in various tumor tissues and cells.In addition;the expression of DEC1 in the tumor tissue is related to the malignancy of various cancer types.This paper;therefore;focuses on the relationship between DEC1 and proliferation;apoptosis;cellular senes-cence;invasion and metastasis of tumor cells;in order to elaborate the role of DEC1 in the pathogenesis and pro-gression of tumor.
