Crystal form identification of dasatinib in tablets
10.11665/j.issn.1000-5048.20150510
- VernacularTitle:达沙替尼原料药的晶型分析
- Author:
Jianming WANG
;
Yanmei CHEN
;
Hailu ZHANG
;
Yanfeng ZHANG
;
Minhua CHEN
- Publication Type:Journal Article
- Keywords:
dasatinib;
polymorph;
X-ray powder diffraction;
solid-state nuclear magnetic resonance;
crystal form identification
- From:
Journal of China Pharmaceutical University
2015;(5):575-578
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to establish the methods to identify crystal form of dasatinib in tablets.X-ray powder diffraction(XRPD)and solid-state nuclear magnetic resonance(ssNMR)were used to analyze the crystal form of dasatinib in Sprycel? tablets and Yinishu? tablets.The results showed that monohydrate and anhydrate were identified in Sprycel? and Yinishu? tablets respectively;with no detectable anhydrate in Sprycel? tablets and no detectable monohydrate in Yinishu? tablets.The results of XRPD and ssNMR were consistent;and could be both applied in the crystal form identification of dasatinib in tablets.
