P2 X7 receptor and renal diseases
10.11665/j.issn.1000-5048.20150519
- VernacularTitle:P2 X7受体和肾脏疾病
- Author:
Hui LIU
;
Xu JI
- Publication Type:Journal Article
- Keywords:
P2X7 receptor;
renal diseases;
inflammation;
new therapeutic target
- From:
Journal of China Pharmaceutical University
2015;(5):629-634
- CountryChina
- Language:Chinese
-
Abstract:
P2 X7 receptor is a member of ATP-gated non-selective cation channels;and is one subtype family of the P2X purinergic receptor.Signaling pathways of P2X7 receptor couple with several key inflammatory molecules including IL-1β;IL-6 and COX-2;which suggests that P2 X7 receptor plays a key role in the development of dis-eases via increased inflammation;indicating its potential as a novel therapeutic target.Recent studies show that P2 X7 receptor has a relationship with renal diseases.This article reviews the effect of P2 X7 receptor on renal diseases and its mechanism.P2 X7 receptor may be a new drug target;and its selectivity antagonist may be a new therapeutic agent for the treatment of renal diseases.
