The expression of eIF4E,VEGF-A and VEGF-C in gastric carcinoma tissues and their correlation with lymph node invasion and metastasis
10.3969/j.issn.1673-4130.2015.20.007
- VernacularTitle:eIF4E、VEGF-A和VEGF-C在胃癌组织中的表达及其与淋巴结侵袭转移的相关性
- Author:
Shiqiao ZHAO
;
Zhongyu CHEN
;
Wei DENG
;
Renzhi HU
;
Min LI
- Publication Type:Journal Article
- Keywords:
invasion;
metastasis;
eukaryofic initiation factor 4E;
vascular endothelial grow th factor
- From:
International Journal of Laboratory Medicine
2015;(20):2937-2939
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of eukaryotic initiation factor 4E(eIF4E) ,vascular endothelial growth factor (VEGF)‐A and VEGF‐C in gastric cancer tissues and their correlation with invasion and metastasis of gastric carcinoma .Methods The expressions of eIF4E ,VEGF‐A and VEGF‐C were detected in tissues of 58 gastric carcinomas and 25 normal gastric mucosa by using immunohistochemical method .Results The positive rate of eIF4E、VEGF‐A and VEGF‐C protein expression were 89 .7%(52/58) ,65 .5% (38/58) ,60 .3% (35/58) in gastric carcinoma ,which were higher than those in normal gastric mucosa tissues which were 4 .0% (1/25) ,12 .0% (3/25) ,8 .0% (2/25) respectively .Expressions of eIF4E ,VEGF‐A and VEGF‐C were significantly correlated with the depth of invasion and lymph node metastasis(P<0 .05) ,but not with the age ,sex of patients(P>0 .05) .Ex‐pressions of eIF4E and VEGF‐C were significantly correlated with tumor differentiation .The expression of eIF4E was being found positively correlated with VEGF‐A and VEGF‐C .Conclusion eIF4E may play certain roles in the oncogenesis and progression of gastric carcinoma .VEGF‐A and VEGF‐C may be helpful in lymph metastasis .Combined detection of eIF4E ,VEGF‐A and VEGF‐C may be helpful to assess the malignant degree and prognosis of gastric carcinoma .
