Expression and significance of 12-lipoxygenase in human glioma

VernacularTitle:12-LOX在神经胶质瘤中的表达及临床意义
Author: Ruixiang GE ; Lili SHENG ; Shanshui XU ; Yinhua LIU ; Guoxiang XU ; Sansong CHEN ; Jie MAO
Publication Type:Journal Article
Keywords: 12-LOX; glioma; prognosis
From: Chinese Journal of Clinical Oncology 2015;42(19):953-956
CountryChina
Language:Chinese
Abstract: Objective:To investigate the expression and clinical significance of 12-lipoxygenase (12-LOX) in glioma. Methods:12-LOX expression in 40 glioma cases and 10 normal human-brain tissues was assayed by immunohistochemistry. Clinicopathological data were analyzed to reveal the association between 12-LOX expression and prognosis of glioma patients. Results:12-LOX was weak-ly expressed in the normal human brain tissues, whereas 12-LOX was strongly expressed (72.5%) in glioma tissues (P<0.05). The strong 12-LOX expression was correlated with the histopathological grading of glioma (P=0.012), whereas 12-LOX expression was not correlated with factors such as patient gender and age, tumor size, and Karnofsky Performance Score. Median survival time was longer in the group with low 12-LOX expression (25.6 months) than in the group with high 12-LOX expression (13.2 months) (P<0.05). Con-clusion:Abnormal 12-LOX expression is implicated in glioma. 12-LOX expression was correlated with the histopathological grading of glioma and was closely associated with patient prognosis.