Research advances in the mechanism and role of CDK6 in tumorigenesis
10.3969/j.issn.1000-8179.2015.19.661
- VernacularTitle:CDK6导致肿瘤的机制研究进展
- Author:
Yinan DONG
;
Xinwei ZHANG
;
Feng WEI
- Publication Type:Journal Article
- Keywords:
CDK6;
cancer;
cell cycle;
cell differentiation;
inhibitor
- From:
Chinese Journal of Clinical Oncology
2015;42(19):973-977
- CountryChina
- Language:Chinese
-
Abstract:
Cell-cycle deregulation leading to excessive cellproliferation is an important mechanism of human tumorigenesis. CDK6 and CDK4 have been found to be significant regulators of cellcycle, particularly in promoting cell -cycle progress. Moreover, these proteins are usually overly active in most tumors and closely related to tumor development. Recently, research has confirmed CDK4/6 as prospective targets for cancer therapy. However, the mechanism of excessive CDK6 activation leading to tumorigenesis is not completely understood. Therefore, further understanding of the role of CDK4/6 in cell -cycle regulatory pathways and celldifferenti-ation is essential, as well as their overexpression in different types of tumors. This information will elucidate the mechanisms of tumor development and treatment. Therefore, this review intends to discuss the structure and biological function of CDK6, the role and mecha-nism of CDK6 in carcinogenesis, and the clinical application of CDK6 inhibitors.
