Progress in association of RSK2 with malignancies and its inhibitors
10.3969/j.issn.1000-4718.2015.10.008
- VernacularTitle:RSK2与恶性肿瘤的关系及其抑制剂的研究进展
- Author:
Kangxing CHEN
;
Ziyou WANG
;
Yanxia HUANG
;
Chengzhi ZHONG
;
Kaiheng LI
;
Zunnan HUANG
- Publication Type:Journal Article
- Keywords:
Ribosomal S6 kinase 2;
Structure;
Function;
Tumor;
Inhibitors
- From:
Chinese Journal of Pathophysiology
2015;(10):1772-1779
- CountryChina
- Language:Chinese
-
Abstract:
RibosomalS6kinase2(RSK2)isamemberofthep90Rsk,whichbelongstoSer/Thrkinasefami-ly.It is a downstream molecule of Ras/MAPK cascade and regulates a variety of cellular processes.RSK2 plays a key role in the cell proliferation, survival and transformation.Furthermore, the aberrant up-regulation of RSK2 was observed in dif-ferent malignancies.We here briefly review the structure and function of RSK2, the relationship between RSK2 and tumor, and the existing RSK2 inhibitors.
