Research advances in the mechanisms of active components in Chinese materia medica against oxidative stress-induced neuronal apoptosis
10.11665/j.issn.1000-5048.20150503
- VernacularTitle:中药有效成分抑制氧化应激诱导的神经细胞凋亡机制研究进展
- Author:
Kai SHEN
;
Junping KOU
;
Boyang YU
- Publication Type:Journal Article
- Keywords:
active components in Chinese materia medica;
neuron;
oxidative stress;
apoptosis;
neurodegenerative disease
- From:
Journal of China Pharmaceutical University
2015;(5):532-540
- CountryChina
- Language:Chinese
-
Abstract:
Oxidative stress-induced neuronal apoptosis plays a vital role in the development of neurodegenerative disorders;while at present its regulation pathways mainly include the NF-κB pathway;p53 pathway;MAPK path-way;PI3 K/Akt pathway;Nrf2 pathway;as well as other signaling pathways.Research findings suggest that the active components in Chinese materia medica exert significant biological activities in the treatment of oxidative stress-induced neuronal apoptosis.In the present paper;we review the recent research advances on the relative mechanisms of active components in Chinese materia medica against oxidative stress-induced neuronal apoptosis;so as to provide some references or clues for the clarification of possible mechanisms of active components in Chinese materia medica and the treatment of related neurodegenerative diseases.
