The changing trend of serum 4 183Da dermcidin peptide fragment after early antithrombotic interference therapy in patients with acute coronary syndrome
10.3969/j.issn.1008-9691.2015.05.008
- VernacularTitle:急性冠脉综合征早期抗栓干预治疗后血清dermcidin蛋白片段4183Da多肽的变化趋势
- Author:
Haijing SONG
;
Kai FENG
;
Lifeng LIU
;
Xianhua LIU
;
Xiaodong FAN
;
Mingzhi WANG
;
Hu XIA
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
Aspirin;
Dermcidin;
4 183Da peptide fragment;
Anti-thrombus therapy;
Myoglobin;
Cardiac troponin I;
MB isoenzyme of creatine kinase
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2015;22(5):482-485
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the profile of dermcidin (DCD) changes in different stages of acute coronary syndrome (ACS) by quantifying the serum 4 183Da DCD peptide fragment deriving from different ACS patients treated with early antithrombotic therapy.Methods A total of 118 patients with confirmed diagnosis of ACS were enrolled. Immediately after visiting a doctor, the venous blood was collected and afterwards instantly the patient was given orally 300 mg of aspirin and 300 mg clopidogrel, and according to the patient's condition and the consent of his/her or acknowledgement of family members achieved, emergency percutaneous coronary interference (PCI) or thrombolysis or conservative treatment was adopted separately. After anti-thrombotic treatment, at 2, 4, 6, 8, 10, 12, 16, 20, 24, 32, 40, 48, 60 and 72 hours, venous blood was collected and serum isolated respectively. The concentration of 4 183Da DCD fragment in serum was determined by matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS). Simultaneously, the myoglobin (Myo), cardiac troponin I (cTnI) and MB isoenzyme of creatine kinase (CK-MB) were also detected.Results The mean relative strength of nature logarithmic transformations of 4 183Da DCD fragment of 118 patients with ACS was 2.75±1.02 before treatment on admission, and after intervention therapy (mainly antithrombotic therapy) it was decreased to 1.84±1.19 (P = 0.005) and 1.74±1.12 (P = 0.000) at 2 hours and 4 hours, respectively, and then after 4 hours it was slightly elevated. 4 183Da polypeptide increased earlier than myocardial injury markers.Conclusion Aspirin and clopidogrel can significantly decrease the concentration of 4 183Da DCD peptide fragment in serum in patients with ACS, which indicates that the DCD fragment could be used as one of the indexes for observation on early efficacy of antithrombotic therapy.
