A clinical observation on correlations between glycosylated hemoglobin level and traditional Chinese medicine syndrome differentiations in young and middle-aged type 2 diabetic patients with heart failure and preserved ejection fraction
10.3969/j.issn.1008-9691.2015.05.013
- VernacularTitle:中青年2型糖尿病合并射血分数保留心力衰竭患者中医证型与糖化血红蛋白相关性的临床观察
- Author:
Minyu LIN
;
Shaobin LIN
;
Bijing YU
- Publication Type:Journal Article
- Keywords:
Young and middle-aged type 2 diabetes;
Heart failure with preserved ejection fraction;
Glycosylated hemoglobin;
Traditional Chinese medicine syndrome types of heart failure
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2015;22(5):504-507
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate traditional Chinese medicine (TCM) syndrome differentiations and glycosylated hemoglobin (HbA1c) levels in the young and middle-aged type 2 diabetic patients with heart failure and preserved ejection fraction (HF-PEF), and to evaluate the correlations between them.Methods 235 out- and hospitalized patients with type 2 diabetes from Department of Cardiology of Affiliated Fuzhou Second Hospital of Xiamen University were enrolled. They were divided into HF-PEF group (120 cases) and non-HF-PEF (HF-NPEF) group (115 cases) according to the diastolic function results of echocardiography. In the HF-PEF group, according to the TCM differentiation of syndromes, the patients were subdivided into four types: heart Qi and Yin deficiency, Yang deficiency of heart and kidney, Qi deficiency and blood stasis and edema syndrome due to Yang deficiency syndromes. The HbA1c levels of different TCM syndromes in HF-PEF and HF-NPEF groups were determined by high performance liquid chromatography. The patients of HF-PEF were further divided into two groups according to serum HbA1c levels > 7.0% or ≤ 7.0%, and the relationships between different serum HbA1c levels and different severity of TCM syndrome types of patients with HF-PEF were compared.Results The level of serum HbA1c in HF-PEF group was significantly higher than that in HF-NPEF group in patients with type 2 diabetes [(7.02±0.74)% vs. (6.79±0.91)%,P < 0.05]. There was no significant difference in HbA1c levels between heart Qi and Yin deficiency type and Yang deficiency of heart and kidney type in HF-PEF group [(6.70±0.66)% vs. (6.70±0.68)%,P > 0.05], while the HbA1c levels of Qi deficiency and blood stasis and edema syndrome due to Yang deficiency syndromes were significantly higher than those of heart Qi and Yin deficiency and Yang deficiency of heart and kidney types [(7.15±0.70)%, (7.55±0.62)% vs. (6.70±0.66)%, (6.70±0.68)%], and the HbA1c levels of edema syndrome due to Yang Deficiency was obviously higher than that of Qi deficiency and blood stasis (P < 0.01). In group of HbA1c > 7.0%, the incidence rate of Qi deficiency and blood stasis and edema syndrome due to Yang Deficiency types was higher than that of the group of HbA1c ≤ 7.0% [61.97% (44/71) vs. 38.78% (19/49),P < 0.05]. Pearson correlation analyses indicated that the number of patients with HF-PEF was positively correlated with HbA1c level in HF-PEF group (r = 0.610,P < 0.05); the HbA1c level was positively correlated with the number of patients with Qi deficiency and blood stasis and edema syndrome due to Yang Deficiency in HF-PEF group with HbA1c > 7.0% (r = 0.683,P < 0.05).Conclusion Clinically using serum HbA1c level to assess the prognosis of HF-PEF has obtained consistent results, and the level is positively correlated to the development of TCM syndrome types in young and middle-aged HF-PEF patients with type 2 diabetes.
