Effect of modified electroconvulsive therapy with different anesthetics on efficacy of patients with treatment-resistant depression

VernacularTitle:不同麻醉剂无抽搐电休克治疗难治性抑郁症的疗效比较
Author: Xingbing HUANG ; Fang MEI ; Xiong HUANG ; Hongbo HE ; Bin SUN ; Chunping ZHANG
Publication Type:Journal Article
Keywords: Modified electroconvulsive therapy; Treatment-resistant depression; Ketamine; Propofol
From: The Journal of Practical Medicine 2015;(17):2808-2811
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of modified electroconvulsive therapy (MECT) with different anesthetics on efficacy of patients with treatment-resistant depression (TRD). Methods Ninety patients with TRD were enrolled in this study to receive a standard 8 times MECT. The HAMD-17 scale was evaluated before MECT and after the completion of the first, second, third, forth, sixth and eighth MECT session. The TESS scale was evaluated before MECT and after the completion of the last MECT session. Results Scores of HAMD-17 after the completion of the first, second, third, fourth, sixth and eighth MECT session were significantly reduced (P<0.05). There were significant differences of HAMD scales among the three groups since the first MECT session (P < 0.05). The remission rate of ketamine group, propofol group and mixed group was 96.7%, 43.3%, and 73.3% (P < 0.05). Conclusion MECT of ketamine anesthetic might contribute to the best effect of TRD.