Difference in sputum concentrations of mucin in eosinophilic bronchitis and asthma
10.3969/j.issn.1006-5725.2015.17.016
- VernacularTitle:嗜酸粒细胞性支气管炎与支气管哮喘患者诱导痰黏蛋白水平的差异机制研究
- Author:
Wei LUO
;
Chaopei YANG
;
Hui WANG
;
Ruchong CHEN
- Publication Type:Journal Article
- Keywords:
Eosinophilic bronchitis;
MUC5AC;
MUC5B;
LTC4;
PGE2
- From:
The Journal of Practical Medicine
2015;(17):2815-2818
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigated the difference in induced sputum concentrations of mucin between the patients with eosinophilic bronchitis (EB) and classic asthma, and found out the difference in mechanism. Methods 20 patients with eosinophilic bronchitis (EB), 20 patients with classic asthma and 10 healthy controls were enrolled. Induced sputum levels of MUC5AC, MUC5B, LTC4 and PGE2 were measured by enzyme immunoassay in patients and healthy control. Results In patients with asthma, sputum MUC5A (26.8 ± 8.5)μg/mL and LTC4 (700.8 ± 172.3)pg/mL were significantly elevated whereas MUC5B levels (1.1 ± 0.5)μg/mL were reduced compared with patients with EB MUC5AC:( 17 . 6 ± 7 . 0 )μg/mL , LTC4:( 320 . 9 ± 89 . 4 ) pg/mL , MUC5B:(2.6 ± 0.5)μg/mL and healthy controls MUC5AC:(12.5 ± 4.3)μg/mL, LTC4:(91.2 ± 16.1)pg/mL, MUC5B:(2.6 ± 0.4)μg/mL (P < 0.01). PGE2 levels were higher in patients with EB (433.8 ± 118.1)pg/mL than in asthma(172.7 ± 74.5)pg/mL and controls(113.3 ± 18.3)pg/mL(P < 0.01), but results did not differ between asthma and controls. The LTC4 showed a significant positive correlation with MUC5AC (r = 0.785,P < 0.01), and a significant negative correlation with MUC5B (r = -0.703,P < 0.01). Conclusion A significant difference in MUC5AC/MUC5B ratio was founded in proximal airway between EB and asthma. The unbalance level between LTC4 and PGE2 would be involved in the pathogenesis of airway mucus hypersecretion.
