Review of Catalpol’s pleiotropic signaling pathways
10.3969/j.issn.1001-1978.2015.09.002
- VernacularTitle:梓醇多效性相关信号通路研究进展
- Author:
Jinghuan WANG
;
Li ZOU
;
Dong WAN
;
Huifeng ZHU
;
Yuan WANG
;
Lei QIN
- Publication Type:Journal Article
- Keywords:
Catalpol;
signaling pathways;
PI3K/AKT;
BDNF;
ACh;
JAK2 /STAT3;
MAPK
- From:
Chinese Pharmacological Bulletin
2015;(9):1189-1194
- CountryChina
- Language:Chinese
-
Abstract:
Catalpol is a kind of iridoid,which has wide pharma-cological activities,including anti-cerebral ischemia,improving senile dementia,anti-inflammation,inhibiting capillary permea-bility,relieving pain,anti-tumor,antidiarrheal,reducing blood sugar level,protecting liver,and anti-aging.The mechanisms of Catalpol effects have been well studied.Signaling pathways in-clude NF-κB signaling pathway,PI3K/AKT signaling pathway, BDNF /TrkB signaling pathway,JAK2 /STAT3 /angiogenesis sig-naling pathway,MAPK signaling pathway,TGF-β/Smad signa-ling pathway,and ACh signaling pathway.We reviewed related signaling pathways of Catalpol effects,in order to broaden the understanding of molecular mechanism and signaling pathways of Catalpol,to know the status of catalpol,and to provide new di-rection to study Catalpol.
