Progress in treatment of cancer targeting MTH1
10.3969/j.issn.1001-1978.2015.09.004
- VernacularTitle:靶向 MTH1治疗肿瘤的研究进展
- Author:
Ying SHEN
;
Peiliang SHEN
;
Xu WANG
;
Aiyun WANG
;
Wenxing CHEN
;
Shizhong ZHENG
;
Yin LU
- Publication Type:Journal Article
- Keywords:
MTH1;
tumor;
molecular mechanisms;
DNA repli-cation;
oxidative damage;
therapy strategies
- From:
Chinese Pharmacological Bulletin
2015;(9):1199-1201
- CountryChina
- Language:Chinese
-
Abstract:
MTH1 (MutT Homolog1 )as MutT homologous en-zyme,is a nucleotide pyrophosphatase,mainly involved in DNA damage repair process,especially plays an important role in the process of DNA replication in tumor cells.Recent studies have found that MTH1’s function is responsible for the development of a variety of tumors.Studies have shown that,MTH1 can remove tumor cells’oxidative DNA elements detrimental to the function-al structure,protecting tumor cell division and proliferation, maintaining tumor cell survival,however,normal cells do not need MTH1.Therefore,MTH1 may be only closely associated with abnormal cell growth.This makes MTH1 as therapeutic tar-gets that have been paid much attention.This article reviewed the relationship of MTH1 and tumor,discussed the mechanisms of MTH1 in tumor growth MTH1 and tumor treatment,so as to provide reference for clinical research and treatment of tumor.
