Nuclear receptors as drug targets in cholestasis
10.3969/j.issn.1001-1978.2015.09.003
- VernacularTitle:以核受体为靶标的胆汁淤积治疗药物研究进展
- Author:
Pan CHEN
;
Jingjie LI
;
Jie CHEN
- Publication Type:Journal Article
- Keywords:
cholestasis;
FXR;
PXR;
CAR;
VDR;
GR;
LXR;
PPAR
- From:
Chinese Pharmacological Bulletin
2015;(9):1195-1198
- CountryChina
- Language:Chinese
-
Abstract:
Drug for cholestasis therapy is extremely limited.Ur-sodeoxycholic acid is currently the only FDA approved drug to treat primary biliary cirrhosis,whereas its efficacy is limited to early stage of the disease.Therefore,developing novel drugs re-presents a major goal for both pharmaceutical industry and aca-demic researchers.Targeting nuclear receptors in cholestasis is an intriguing approach since these receptors are critically in-volved in the regulation of bile acid homeostasis.This review summarizes the roles of individual nuclear receptors in cholestasis and evaluates their potential clinical application.
