Recent Advances in Mitochondrial Proteomics
10.11895/j.issn.0253-3820.150479
- VernacularTitle:线粒体蛋白质组学研究进展
- Author:
Jingyi XU
;
Chaoxiang CHEN
;
Jinyan HAN
;
Wei HANG
;
Xiaomei YAN
- Publication Type:Journal Article
- Keywords:
Mitochondria;
Proteomics;
Mass spectrometry;
Disease;
Review
- From:
Chinese Journal of Analytical Chemistry
2015;(9):1257-1264
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria play a central role in the regulation of cellular energy metabolism, bio-synthesis and cell death. Dysfunction of mitochondria can lead to many diseases. Mitochondrial proteomics provides important theoretical foundation for a systematic understanding of the biological functions of mitochondria, studying the mechanisms of mitochondria-related diseases, and promoting the research and development of mitochondria-targeting drugs. The methodologies, recent technology development, and characteristics and applications of mitochondrial proteomics were reviewed and the challenges and prospects were also discussed.
