Nano-hydroxyapatite/polyamide 66 composite for repair of early femoral head necrosis
10.3969/j.issn.2095-4344.2015.34.011
- VernacularTitle:纳米羟基磷灰石复合聚酰胺66材料修复早期股骨头坏死
- Author:
Mingmin YANG
;
Dai LI
;
Yang SUN
- Publication Type:Journal Article
- Keywords:
Hydroxyapatites;
Nylons;
Femur Head Necrosis
- From:
Chinese Journal of Tissue Engineering Research
2015;(34):5463-5467
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Nano-hydroxyapatite/polyamide 66 composite has good material-cel interface and three-dimensional porous network structure, and it can also be gradualy degraded over time after implantation in the human body. OBJECTIVE:To explore the effect of nano-hydroxyapatite/polyamide 66 in early repair of femoral head necrosis. METHODS:A retrospective analysis was performed on clinical data of 62 cases of early osteonecrosis of the femoral head, including 32 males and 30 females, aged 34-51 years. These patients were divided into control group (31 cases) and observation group (31 cases) according to treatment methods. Core decompression with nano-hydroxyapatite/polyamide 66 implantation and core decompression with bone graft were respectively performed in the observation and control groups. Incidence of pain in the two groups was compared at 1 day after treatmen; and during the 12-month folow-up, the Harris score of the hip function in the two groups was compared. RESULTS AND CONCLUSION:There was no significant difference in the visual analog scale scores between two groups at 1 day after treatment. The Harris scores in the observation group were significantly higher than those in the control group at 3 and 12 months after treatment (P < 0.05). There was no adverse reaction in the two groups. These findings indicate that nano-hydroxyapatite/polyamide 66 material for repair of early femoral head necrosis has good biocompatibility, and can obtain good effects on limb function recovery.
