The clinical study of efficacy of cyclophosphamide plus MP for patients with multiple myeloma and its influ-ence on serum CRP,LDH,Alb and β2 -MG
10.3760/cma.j.issn.1008-6706.2015.17.003
- VernacularTitle:环磷酰胺联合MP方案治疗多发性骨髓瘤的疗效及对血清C反应蛋白、乳酸脱氢酶、白蛋白和β2微球蛋白的影响
- Author:
Ling WU
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Cyclophosphamide;
MP;
CRP;
LDH;
Albumin;
β2 -microglobulin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(17):2567-2570
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic efficacy and safety of cyclophosphamide combined with MP for patients with multiple myeloma (MM),as well as its influence on serum CRP,LDH,albumin (Alb)and β2 -microglobulin (β2 -MG).Methods 6 1 patients diagnosed MM in our hospital were divided into two groups random-ly:32 cases in the treatment group were given the regimen of cyclophosphamide combined with MP,and 29 cases in the controlled group were given the regimen of MP.After four periods of treatment,the curative effects and side effects of two groups were evaluated,besides,the changes of serum CRP,LDH,Alb and β2 -MG were compared.Results In the treatment group,the ORR was 90.63%,CR was 37.50%,VGPR was 25.00%,PR was 28.13%.And in the controlled group,the ORR was 62.06%,CR was 10.34%,VGPR was 17.24%,PR was 34.48%.The further studies shows that the CR and ORR between the two groups were significantly different (χ2 =6.050,7.015,P=0.013, 0.008).Moreover,the side effects included hematological toxicities and non-hematological toxicities which were not different notably (P>0.05).In addition,the serum CRP,LDH andβ2 -MG were decreased after the treatment nota-bly (t=7.321,4.972,7.668,5.174,4.231,2.379,all P<0.05),especially in the treatment group (t=-2.097,-2.409,-2.112,all P<0.05);the Alb was increased compared to precious notably (t=-4.170,-2.805,all P<0.05),especially in the treatment group (t=1.710,P<0.05).Conclusion The regimen of cyclophosphamide com-bined with MP is an effective and safe therapy for multiple myeloma which seems significantly superior to MP regimen with higher CR and ORR and which can also lower CRP,LDH,β2 -MG and raise Alb to cut down the burden of tumor.
