The comprehensive prevention strategy for occurrence and risk factors of haploidentical hematopoi-etic stem cell transplantation associated oral mucositisunder
10.3760/cma.j.issn.1672-7088.2015.26.004
- VernacularTitle:综合预防策略降低半相合造血干细胞移植口腔黏膜炎发生率及影响因素研究
- Author:
Wei HU
;
Xiaodong MO
;
Xia YAN
;
Xiaodong XU
;
Shuang DONG
;
Yanchao CAO
;
Xiujuan GUO
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Oral mucositis;
Comprehensive prevention
- From:
Chinese Journal of Practical Nursing
2015;(26):1962-1966
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the comprehensive prevention strategy in the prevention of oral mucositis (OM) during allogeneic hematopoietic stem cell transplantation (HSCT). Methods A total of 721 patients who received HSCT from January 2010 to December 2011 at the Institute of Hematology, Peking University were enrolled. All the patients received the comprehensive prevention strategy of OM. Results A total of 315 patients (43.7 percents) suffered from OM during HSCT, the median time from HSCT to OM occurrence was 5 days. There were 173 (54.9 percents), 91(28.9 percents), 37(11.7 percents), and 14(4.4 percents) patients suffered from gradeⅠ,Ⅱ,Ⅲ, and IV OM, respectively. Tongue OM was most common. A total of 111 patients suffered from multiple OM (≥2 locations). Multiplicity showed that duration of agranulocytosis≥15 days was the only independent risk factor of OM in HSCT [ hazard ratio (HR) value 1.5, P<0.05 ]. Neutrophil engraftment time≥12 days was significantly associated with prolonged OM (≥8 days) (HR=2.1, P<0.05). Patient age ≥20 was independent risk factor for occurrance of grade Ⅲ-Ⅳ OM (HR=2.7, P<0.05). Conclusions Comprehensive prevention strategy can overcome the risk factors of OM and prevent the occurrence of OM during HSCT.
