Intra-articular injection of biological agents for treatment of osteoarthritis：effects on the articular cartilage and its function
10.3969/j.issn.2095-4344.2015.34.029
- VernacularTitle:关节腔内注射生物制剂修复膝关节骨性关节炎：对关节软骨及功能的影响
- Author:
Jun WU
;
Suohua PAN
;
Liqin WANG
;
Ying LI
- Publication Type:Journal Article
- Keywords:
Hyaluronic Acid;
Betamethasone;
Osteoarthritis,Knee
- From:
Chinese Journal of Tissue Engineering Research
2015;(34):5566-5571
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Hyaluronic acid or compound betamethasone for treatment of knee osteoarthritis can reduce inflammatory reactions in the joints, relieve pain, and protect the function of the knee joint. OBJECTIVE:To investigate the clinical efficacy of intra-articular injection of hyaluronic acid combined with compound betamethasone on middle-stage knee osteoarthritis as wel as protective effect on joint function. METHODS:A total of 100 patients with II, III knee osteoarthritis were randomly divided into two groups: intra-articular injection of hyaluronic acid (2 mL) as control group and intra-articular injection of hyaluronic acid (2 mL) combined with compound betamethasone (1 mL) as testing group. The intra-articular injection was carried out once a week, totaly for consecutive 5 weeks. Visual analog scale score, Lysholm knee joint score and erythrocyte sedimentation rate were compared between two groups before and after treatment. RESULTS AND CONCLUSION:After treatment, the visual analog scale score, Lysholm knee joint score and erythrocyte sedimentation rate were improved significantly in the two groups as compared with those before treatment (P < 0.05); in addition, these parameters were al better in the testing group than the control group (P < 0.05). No systemic adverse reactions occurred in the two groups. These findings indicate that the intra-articular injection of hyaluronic acid combined with compound betamethasone can reduce inflammatory reactions, relieve pain, and improve joint function.
