Polymorphisms in p.S267F of SLC10A1 gene is associated with clinical outcomes of HBV infection
10.3760/cma.j.issn.1674-2397.2015.05.006
- VernacularTitle:SLC10A1基因p．S267F位点单核苷酸多态性与HBV感染临床转归之间的相关性
- Author:
Qiang LI
;
Qibin ZHUO
;
Shuye ZHANG
;
Yuxian HUANG
;
Liang CHEN
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Sodium taurocholate cotransporting polypeptide;
Polymorphism,single nucleotide;
Clinical outcomes
- From:
Chinese Journal of Clinical Infectious Diseases
2015;(5):425-428
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of restriction fragment length polymorphisms (RFLP) in p.S267F of SLC10A1 gene with clinical outcomes of hepatitis B virus (HBV) infection. Methods Clinical data of 1 268 patients with HBV infections admitted in Public Health Clinical Center Affiliated to Fudan University during July 2014 and February 2015 were collected.Polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP) method was used to genotype the p .S267F of SLC10A1 gene in all patients, and the potential association between variants in p .S267F of SLC10A1 gene and the clinical outcomes of HBV infection was analyzed .Results Among 1 268 patients with HBV infections, 1 226 were of genotype CC, and 42 were of genotype CT, so the variation rate in p.S267F was 3.31%(42/1 268).Compared with patients with genotype CC , patients with genotype CT had a higher incidence of acute HBV infections (13.6%vs.28.6%,χ2 =19.819, P<0.05) and a lower incidence of HBV-related liver cirrhosis or hepatocellular carcinoma (13.9% vs.4.8%, χ2 =18.945, P <0.05). Conclusion RFLP in p.S267F of SLC10A1 gene may be associated with chronicity and aggravation of HBV infection, and genotype CT is possibly a protective factor .
