Articular cartilage repair using mesenchymal stem cells-derived microvesicles and induced pluripotent stem cells
10.3969/j.issn.2095-4344.2015.41.026
- VernacularTitle:间充质干细胞源性微囊泡和诱导性多潜能干细胞促进关节软骨修复的进展
- Author:
Weiyu HOU
;
Yanwei CHENG
;
Chuan XIANG
- Publication Type:Journal Article
- Keywords:
Cartilage Diseases;
Cartilage,Articular;
Induced Pluripotent Stem Cels;
Mesenchymal Stem Cels;
Tissue Engineering
- From:
Chinese Journal of Tissue Engineering Research
2015;(41):6706-6710
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Induced pluripotent stem cels and mesenchymal stem cels-derived microvesicles have been confirmed in various tissue repairs, which are expected to become more effective and safe therapy for articular cartilage repair. OBJECTIVE:To overal understand the research progress in the use of induced pluripotent stem cels and mesenchymal stem cels-derived microvesicles in articular cartilage repair. METHODS: A computer-based search of PubMed and CNKI was performed by the first author for articles related to stem cel treatment of osteoarthritis published from 2003 to 2015. The keywords were “articular cartilage injury, bone marrow mesenchymal stem cels” in English and Chinese, respectively. In the same field, articles published recently or in authorized journals were preferred. RESULTS AND CONCLUSION:Articular cartilage injury is stil a difficulty in the orthopedics. Many repair methods have been reported, but they al have limitations. Induced pluripotent stem cels and mesenchymal stem cels-derived microvesicles bring a new hope for patients with articular cartilage injury. However, there are stil many problems to be solved, such as extracting and purifying a large amount of cels, proliferation and differentiation potentials, and mechanism underlying cartilage repair.
