The role of matrix metalloproteinases in intervertebral disc degeneration

VernacularTitle:椎间盘退变中基质金属蛋白酶作用的研究进展
Author: Xiaozhou LIU ; Haidong XU ; Guangxin ZHOU ; Jianning ZHAO
Publication Type:Journal Article
Keywords: Intervertebral disc degeneration; Matrix metalloproteinases; Expression and regulation
From: Journal of Medical Postgraduates 2015;(11):1213-1217
CountryChina
Language:Chinese
Abstract: Intervertebral disc degeneration is one of the orthopedic common diseases , its complex physiopathological changes are regulated by many factors .The matrix metalloproteinases ( MMPs) and its regulatoryl factors play a very important role , and the factors that affect the role of MMPs in intervertebral disc degeneration interact with each other .So MMPs have gradually become one of the hot spot of intervertebral disc degeneration in recent years .In this paper , we first analyze the factors that cause the degeneration of intervertebral disc .Then we summarize the relationship between the expression of MMPs and the degeneration of intervertebral disc ac -cording to the different function of MMPs members in the family .Finally we state that MMPs can have an effect on the degeneration of intervertebral disc by the regulation of gene polymorphism and the related factors .