Progress of toll-like receptor 4 signaling pathway
10.16571/j.cnki.1008-8199.2015.11.026
- VernacularTitle:Toll样受体4信号通路研究进展
- Author:
Binggang CAI
;
Jin ZHU
;
Maorong WANG
- Publication Type:Journal Article
- Keywords:
Toll-like receptor 4;
Signaling pathway;
Inflammatory response;
Immunoregulation
- From:
Journal of Medical Postgraduates
2015;(11):1228-1232
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract ] Toll like receptor 4 (TLR4) is a key member of the Toll like receptor family , and is a major receptor for lipopo-lysaccharide ( LPS) .After stimulating with LPS , TLR4 activation could cause the release of a series of inflammatory factors , and acti-vate the immune response of the organism .In recent years , LPS/TLR4 signal transduction has been widely studied , and it has become the most important research hotspot in the inflammatory reaction and its control method .In this paper , we review the recent progress of molecules involved in TLR 4 signaling pathway and their regulatory mechanisms .
