Early recognition and treatment of adrenal crisis in children
10.3760/cma.j.issn.1673-4912.2015.10.002
- VernacularTitle:儿童肾上腺危象的早期识别与治疗
- Author:
Yucai ZHANG
;
Yuqian REN
- Publication Type:Journal Article
- Keywords:
Adrenal crisis;
Adrenal insufficiency;
Diagnosis;
Treatment;
Children
- From:
Chinese Pediatric Emergency Medicine
2015;22(10):672-675
- CountryChina
- Language:Chinese
-
Abstract:
Adrenal crisis is a life-threatening emergency caused by the destruction or altered function of the adrenal gland with a primary deficit in cortisol secretion(primary adrenal insufficiency)or by hypotha-lamic-pituitary pathologies determining a deficit of adrenocorticotropic hormone(secondary adrenal insuffi-ciency).Infection and abrupt end glucocorticoid treatment are the major precipitating causes of adrenal crisis. Patients with adrenal crisis typically present with hypovolemic shock or hypotension,nausea,vomiting,and fe-ver responding well to parenteral hydrocortisone administration.The main laboratory findings include lower serum cortisol concentrations,hyponatremia,hypoglycaemia and/or hyperkalemia.Delay diagnosis of adrenal insufficiency leads to adrenal crisis which is potentially lethal complication.Empirical glucocorticoid replace-ment should be initiated as soon as the suspicious of adrenal crisis,or sooner if the patient presents in adrenal crisis in critically ill children.
