Correlation study between cerebral microbleeds and early neurological deterioration in patients with first-onset acute lacunar stroke
10.16571/j.cnki.1008-8199.2015.11.010
- VernacularTitle:首发急性腔隙性脑梗死患者脑微出血与早期神经功能恶化的关联研究
- Author:
Zhongkui HAN
;
Mingshan REN
;
Yuanliang XIA
;
Liujun SUO
- Publication Type:Journal Article
- Keywords:
Cerebral microbledds;
Early neurological deterioration;
Lacunar infarction
- From:
Journal of Medical Postgraduates
2015;(11):1160-1163
- CountryChina
- Language:Chinese
-
Abstract:
Objective The predictive indexes which affect early neurological deterioration ( END) of patients with acute la-cunar stroke still remain unclear .The purpose of the article was to investigate the correlation between the location and numbers of cere -bral microbleeds (CMBs) and END in patients with first-onset lacunar stroke. Methods 217 patients with acute lacunar stroke hos-pitalized in Anhui Provincial Hospital within 24 hours after occurrence from Mar 2009 to May 2012 were prospectively enrolled .All pa-tients underwent susceptibility-weighted imaging MRI right after admission , followed by the investigation on the relationship of the loca-tion and numbers of CMBs and END . Results END occurred in 76 (35.0%) patients.Among these patients, there were 33 positive cases with CMBs (43.3%).There were no significant difference in END incidence between positive group and negative group (P=0.173).In the comparison of the numbers of CMBs foci , patients with more than 5 foci were more prone to END (P=0.005).Logistic regression analysis showed there was relation between CMBs foci numbers>5 and END (OR=3.14, 95% CI: 1.22 ~8.13), and there was no relation between CMBs foci numbers≤5 and END ( OR=1.12, 95%CI:0.53~2.37)as to CMBs negative patients.No signifi-cant relationship was found in CMBs location and END occurrence ( P>0.05). Conclusion The distribution of CMBs foci has nothing to do with early neurological fluctuation .However , more than 5 CMBs foci might be the independent prediction cause of END .
