Research progress on the prevention and treatment of diabetic nephropathy by activated vitamin D3 immu-noregulation
10.16571/j.cnki.1008-8199.2015.11.020
- VernacularTitle:活性维生素 D3通过免疫调节防治糖尿病肾病研究进展
- Author:
Yu ZHAO
;
Xiaoliang ZHANG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Activated vitamin D 3;
Immunoregulation;
Immunocyte;
Cytokines;
RAS
- From:
Journal of Medical Postgraduates
2015;(11):1199-1203
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy is caused by manifold factors .Increasing evidences suggest that immunoregulation abnormality caused by inflammatory cell infiltration and proinflammatory factor overexpression in kidney tissue has a key role in the occurrence and development of diabetic nephropathy .As a novel immunomodulator , activated vitamin D 3 could inhibit inflammatory factor and regulate immunity response .The author reviews the effect of activated vitamin D 3 related to diabetic nephropathy , from the pointviews of immu-nocyte, cytokines and rennin-angiotensin system.The roles of macrophage, T lymphocytes, dendritic cell, transforming growth factor-β1, and rennin-angiotensin system in kidney injury and immunal regulation of activated vitamin D 3 are discussed.
