Comparison of coagulation data measured with domestic produced and imported coagulation testing solutions on SD rat

VernacularTitle:两种不同试剂对 SD 大鼠血凝四项检测结果的比对
Author: Yanxin GAO ; Yujie ZHU ; Mufang LI ; Zhaoxin YANG ; Jian FU
Publication Type:Journal Article
Keywords: Prothrombin time; Activated partial thromboplastin time; Thrombin time(TT); Fibrinogen
From: Chinese Journal of Comparative Medicine 2015;(10):21-23
CountryChina
Language:Chinese
Abstract: Objective To compare coagulation data measured with domestic produced and imported coagulation testing solutions on SD rat and human by testing prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time(TT), fibrinogen(FIB).Methods Blood samples were obtained from SPF SD rat and human .Domestic produced and imported coagulation testing solutions were applied to test PT , APTT, TT, and FIB.Results Compared to rat data measured with imported coagulation testing solution , data measured with domestic produced coagulation testing solution of PT, APTT, FIB was significantly higher (P<0.05), while, data of TT was statistically lower(P<0.05), and there was no obvious difference in human blood coagulation .Conclusion The data measured with different coagulation testing solution varies on SD rat , so the laboratories are required to establish reference data according to different products .