Correlation analysis of the relationship between serum MBL and LPS with body mass index in gestational diabetes mellitus women
10.3969/j.issn.1006-5725.2015.20.012
- VernacularTitle:妊娠期糖尿病孕妇血浆凝集素和内毒素水平与体质指数的相关性
- Author:
Qin LI
;
Jing YUAN
;
Lin CONG
;
Song LI
;
Qin YANG
- Publication Type:Journal Article
- Keywords:
Gestational Diabetes Mellitus;
Mannose-binding lectin;
Lipopolysaccharide
- From:
The Journal of Practical Medicine
2015;(20):3324-3327
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between plasma mannose-binding lectin (MBL), lipopolysaccharide (LPS) and body mass index in pregnant women with gestational diabetes mellitus (GDM). Methods 45 newly diagnosed GDM pregnant women and 45 healthy women (control group) were selected in this study. Plasma concentration of MBL and LPS were measured. All the groups were sub-divided into obesity (BMI ≥ 25 kg/m2) and non-obesity (BMI < 25 kg/m2) subgroup. The relationships of levels of plasma LPS, MBL with BMI were analyzed. Results The level of plasma MBL in GDM group was significantly lower than that in control group(P < 0.05), while the concentration of LPS in serum was much higher than that in healthy pregnant women (P < 0.05). Pearson analysis showed the level of MBL in GDM group was negatively correlated with BMI(r=-0.28, P<0.05), serum LPS concentration was positively correlated with BMI(r = 0.62, P < 0.05) and LPS was negatively correlated With MBL(r = -0.43, P < 0.05) . The above correlations were not found in control group. Conclusion Serum MBL and LPS maybe two important risk factors for those pregnant women being overweight, and could offer great significance for the prevention and treatment of GDM.
