The protective effect of Danggui Buxue decoction on radiation injury in mice

VernacularTitle:当归补血汤对辐射损伤小鼠的防护作用
Author: Jing FENG ; Yuanwang YU
Publication Type:Journal Article
Keywords: Danggui Buxue decoction; Radiation injury; Protective effect
From: Chinese Journal of Comparative Medicine 2015;(10):55-58
CountryChina
Language:Chinese
Abstract: Objective To observe the protective effect of Danggui Buxue Decoction on 60 Co-γray irradiated mice. Methods The experimental mice were randomly divided into 5 groups ( the normal control group , model group , Danggui Buxue Decoction of low , middle and high dose groups ) .The mouse except the normal control group were irradiated by 60Co-γray and established the radiation-damage model.Peripheral blood neutrophil count (NEUT), the number of bone marrow nucleated cells ( BMC ) , the activity of serum superoxide dismutase ( SOD ) and the serum levels of malondialdehyde ( MDA) were measured .Results Radiation injury in mice of NEUT , BMC and SOD were significantly decreased (P <0.01), MDA were increased (P <0.01).Danggui Buxue Decoction can increase the levels of NEUT , BMC and SOD in mice after radiation injury , decrease the content of MDA .And protective effect of high dose group was better (P <0.01).Conclusions Danggui Buxue Decoction has protective effect on radiation injury in mice .And there is a correlation between the protection effect and dose .