The updated research progress of SAMHD1 on the restriction of HIV/SIV replication
10.3969.j.issn.1671.7856.2015.010.017
- VernacularTitle:SAMHD1限制 HIV／SIV 病毒复制功能研究的最新进展
- Author:
Lingjuan PENG
;
Zhe CONG
;
Qiang WEI
- Publication Type:Journal Article
- Keywords:
SAMHD1;
HIV-1;
Vpx
- From:
Chinese Journal of Comparative Medicine
2015;(10):71-74
- CountryChina
- Language:Chinese
-
Abstract:
The host protein SAMHD1 has been identified as the first mammalian deoxynucleoside triphosphate triphosphohydrolase (dNTPase), which blocks the infection of HIV-1 in non-cycling immune cells.SAMHD1 protein is highly expressed in human myeloid-lineage cells and resting CD4+T lymphocytes, which restricts HIV-1 replication by hydrolyzing the cellular dNTPs, thus inhibiting reverse transcription and viral complementary DNA ( cDNA) synthesis. Recent studies have revealed that SAMHD 1 plays an important role in virus whole life by promoting HIV -1 genome recombination, degenerating viral genome RNA and restricting virus transmission between cells .In this review, these progress on SAMHD1 research are summarized and the mechanisms by which SAMHD 1 mediates retroviral restriction are analyzed .
