Subchronic Toxicological Assessment of Diosgenin in Kunming Mice

VernacularTitle:薯蓣皂苷元对昆明鼠的亚慢性毒性实验＊
Author: Yachun GUO ; Gao AN ; Xiaofei ZHAO ; Hongru SONG
Publication Type:Journal Article
Keywords: Diosgenin; Rhizoma Dioscreae Nipponicae; subchronic toxicity; no observed adverse effect dose level
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(9):1823-1827
CountryChina
Language:Chinese
Abstract: This study was aimed to evaluate the subchronic toxicity of diosgenin in mice. A total of 80 mice were divided into 4 groups, which were 0 (control), 100, 200, and 400 mg·kg-1 by the random number table. Intragastric administration was given once a day for 90 days in the assessment of subchronic toxicity of diosgenin among mice. The observed indexes contained body weight, fur color, diet, feces, and etc. The detected indexes contained blood routine analysis, blood biochemistry and pathological examination. The results showed that compared with the control group, the body weights of mice in the male medication group were slight reduced. There were no significant hematologic and pathologic abnormalities. It was concluded that the subchronic toxicity of diosgenin with no observed adverse effect dose level was more than 400 mg·kg-1. The oral administration was relatively safe.