Optimization of Extraction Process for Arctiin and Arctigenin inArctium lappaL. Based on Central Composite Design and Response Surface Methodology

VernacularTitle:星点设计-效应面法优化牛蒡子中牛蒡子苷和牛蒡子苷元提取工艺＊
Author: Enbo CAI ; Wei WANG ; Caixia JIA ; Yan ZHAO ; Dalong WANG ; Xiangxiang LIU ; Dingrong YE ; Limin YANG
Publication Type:Journal Article
Keywords: Arctiin; arctigenin; optimization of extraction; central composite design and response surface methodology
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(9):1828-1832
CountryChina
Language:Chinese
Abstract: This study was aimed to optimize the extraction process of double-marker components for Arctium lappa L. The central composite design and response surface methodology was used. According to 3 main factors, the extraction rates of arctiin and arctigenin was used as evaluation indexes. Multiple linear regression and two-order polynomial equation were used. The binomial fitting model was performed in the optimization of arctiin and arctigenin extraction technology. The results showed that the indentified optimized extraction technology of arctiin and arctigenin was 70% ethanol, 24-fold, ultrasonic solvent extraction for 15 minutes. It was concluded that this technology was able to extract large amount of arctiin and arctigenin, which provided experiment evidences for arctiin and arctigenin preparation. It also provided references for the development and utilization of arctiin and arctigenin.