Analysis of clinicopathological features of gastric cardia cancer with neuroendocrine cell differentiation
10.3760/cma.j.issn.1008-6706.2015.21.001
- VernacularTitle:具有神经内分泌分化性质贲门癌的临床病理特征分析
- Author:
Guangcan CHEN
;
Liangli HONG
;
Aosi XIE
;
Wenting LIN
;
Dan GUO
;
Shuhui LIU
- Publication Type:Journal Article
- Keywords:
Neuroendocrine cell differentiation;
Cardiac tumor;
Immunohistochemistry;
Pathology,clinical
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(21):3201-3203
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological features of gastric cardia cancer with neuroendo-crine cell differentiation(NED).Methods From September 2007 to October 2014,the clinicopathological features of 70 gastric cardia cancer patients with NED and 76 cases without NED confirmed by surgical pathology specimens and immunohistochemistry (Syn and CgA)in the First Affiliated Hospital of Shantou University Medical College were ret-rospectively analyzed and compared.Results The positive expression rates of synaptophysin(Syn)and chromogranin A(CgA)were 43.2% and 22.6%,respectively.Tumor differentiation was significantly related with NED (χ2 =4.989,P =0.026).Tumors with NED were larger and had deeper invasion,but they were not statistically significant. Conclusion Immunohistochemistry is important to the diagnosis of NED.Gastric cardia cancer with NED has poorer differentiation.
