Traditional Chinese Medicine Regulation on Aβ Transporter in Blood-brain Barrier

VernacularTitle:中药调控血脑屏障对Aβ的转运＊
Author: Qianfeng HU ; Chunxiang ZHOU ; Beibei YU
Publication Type:Journal Article
Keywords: Alzheimer’s disease; Aβ; blood-brain barrier; traditional Chinese medicine; RAGE; LRP-1
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(9):1906-1910
CountryChina
Language:Chinese
Abstract: The main pathological change of Alzheimer’s disease (AD) was the formation of senile plaques (SP) induced by the abnormal accumulation ofβ-amyloid protein (Aβ). Blood-brain barrier (BBB) can regulate the Aβ metabolism in the brain through relevant transporter to complete the across BBB transport. This paper introduced two main transporters, which were the receptor for advanced glycation end products (RAGE) and the low density lipoprotein receptor-related protein-1 (LRP-1) in BBB for the elucidation of neuronal cell toxicity induced by inflammatory factors from Aβ accumulation within the brain. It further explored the regulation on two transport proteins, which were RAGE and LRP-1 in BBB for the reduction of abnormal accumulation of Aβ, relieving of inflammation in the brain, and protection of cerebral neurons by traditional Chinese medicine (TCM).