Serum uric acid levels predict the risk of developing prediabetes in an adult population
10.3760/cma.j.issn.1674?0815.2015.05.005
- VernacularTitle:成年人群中基线血清尿酸水平对前期糖尿病的预测价值
- Author:
Qing ZHANG
;
Yeqing GU
;
Xue BAO
;
Li LIU
;
Hongbin SHI
;
Kun SONG
;
Kaijun NIU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Uric acid;
Adult
- From:
Chinese Journal of Health Management
2015;9(5):345-348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate whether the serum uric acid (SUA) levels are related to development of prediabetes. Methods This was a 6-year cohort study, subjects were recruited from Tianjin Medical University General Hospital Health Management Center. A prospective assessment (n=30 910) was performed. Subjects without a history of prediabetes were followed up for 6 years (with a median follow-up of 2.7 person-years). All relevant variables including SUA concentrations, and fasting plasma glucose were assessed at baseline and yearly during the follow-up. Prediabetes was defined in accordance with the American Diabetes Association criteria of 2014. Multivariate-adjusted Cox proportional hazards regression models were fitted to assess relationships between the quintiles of baseline SUA and the incidence of prediabetes. Results The incidence of prediabetes was 55 per 1 000 person-years. In comparison with subjects in the lowest quintile, the odds ratios and hazard ratio (95%confidence interval) of higher quintile of SUA were 1.04 (0.93, 1.15), 1.07 (0.95, 1.19), 1.13 (1.01, 1.28) and 1.15 (1.02, 1.30) (P for trend=0.01), respectively, after adjusting for potential confounders. Conclusion SUA levels predicted an increased risk of prediabetes in adults.
