Research advances in NLRP3 inflammasome
- VernacularTitle:NLRP3炎性小体研究进展
- Author:
Qi WEI
;
Xiaoshu CHENG
- Publication Type:Journal Article
- Keywords:
inflammasome;
NLRP3;
IL-1β
- From:
Basic & Clinical Medicine
2015;(1):117-121
- CountryChina
- Language:Chinese
-
Abstract:
Inflammasomes are multiprotein complexes that can recognize pathogenic microorganisms and stress -asso-ciated endogenous molecules and play an important role in innate immune system .Inflammasomes cause inflamma-tion response by inducing maturation of inflammatory cytokines interleukin ( IL)-1βand IL-18 through activation of caspase-1 ,and involve in the pathogenesis of various diseases such as cryopyrin-associated periodic syndrome , is-chemia-reperfusion injury and atherosclerosis .
