Progress on GSK-3βin cardioprotection against ischemia/reperfusion injury
- VernacularTitle:糖原合成激酶-3β减轻心肌缺血／再灌注损伤的研究进展
- Author:
Qing LI
;
Hua JIANG
;
Juxiang LI
- Publication Type:Journal Article
- Keywords:
glycogen synthase kinase-3β;
mitochondrial permeability transition pore;
signal transduction;
reperfusion injury
- From:
Basic & Clinical Medicine
2015;(1):126-129
- CountryChina
- Language:Chinese
-
Abstract:
Glycogen synthase kinase-3βis a multifunctional Ser/Thr kinase , and its activity has been associated with many cell processes .The mitochondrial permeability transition pore is primed by ischemia to open upon reperfusion , leading to reperfusion induced cell necrosis .Phosphorylated GSK-3βpresumably inhibits mPTP opening by multiple mechanisms , including preservation of hexokinaseⅡin mPTP complex , prevention of interaction of cyclophilin-D with adenine nucleotide translocase , inhibition of P53 activation and attenuation of ATP hydrolysis during ischemia .
