Comparative analysis of HIV disease progression between IDUs with HIV/HCV co-infection and those with HIV infection
10.3760/cma.j.issn.0254-5101.2015.09.013
- VernacularTitle:静脉注射吸毒人群 HIV／HCV 混合感染者与 HIV 单独感染者艾滋病疾病进展比较分析
- Author:
Shifu LI
;
Jincui FU
;
Zaiyou LI
;
Chunyuan GUO
;
Jie XU
;
Jinxian ZHAO
;
Liangmin GAO
- Publication Type:Journal Article
- Keywords:
AIDS;
HIV/HCV co-infection;
Disease progression;
CD4+T cell counts;
Death
- From:Chinese Journal of Microbiology and Immunology
2015;(9):692-697
- CountryChina
- Language:Chinese
-
Abstract:
Objective To comparatively analyze the HIV disease progression and the death situa-tion between injecting drug users (IDUs) with HIV infection and those with HIV/HCV co-infection.Meth-ods The counts of CD4+T cells were collected through a retrospective study and the data about death situa-tion were collected with follow-up cards from 2006 to 2014 .A statistical analysis was conducted for the two groups .Results Among the 175 cases with HIV infection , the average value of primary CD 4+T cell counts was 370 cell/μl and 25.71%of them, primary CD4+T cell counts were less than 200 cell/μl.The average change rate of CD4+T cell counts was -1.50 cell/μl in month.The annual mortality rate was 18.18%. Among the 325 cases with HIV/HCV co-infection, the average value of primary CD4+T cell counts was 420 cell/μl and 20.45%of them, primary CD4+T cell counts were less than 200 cell/μl.The average change rate of CD4+T cell counts was -2.76 cell/μl in month.The annual mortality rate was 32.14%.The differ-ences between the groups were significant (P<0.05).Conclusion Compared with patients with HIV infec-tion, those with HIV/HCV co-infection showed significantly decreased CD 4+T cell counts , resulting in a faster disease progression and a faster death .It was urgent for the management department to work out HIV prevention and therapeutic measures .
