The synergistic effect of estradiol and testosterone on the lipids and coagulation function in mice with hyperlipidemia
10.3969.j.issn.1671.7856.2015.010.007
- VernacularTitle:雌雄激素联合作用对高脂血症小鼠血脂水平及凝血功能的影响
- Author:
Wen DAI
;
Yan LI
;
Hongyun ZHENG
;
Shuwen XU
- Publication Type:Journal Article
- Keywords:
Estrogen;
Androgen;
Hyperlipidemia;
Coagulation function
- From:
Chinese Journal of Comparative Medicine
2015;(10):29-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of synergistic effect of estradiol and testosterone on the level of lipids and coagulation function in mice with hyperlipidemia .Methods We established a maouse model in hyperlipidmia , giving estradiol (1 μg/d), testosterone (7 μg/d) or estradiol combined testosterone (1 μg/d E2 +7Tμg/d), respectively.After 14 weeks, we collected the blood from the mice , separated the serum to detect the lipids level , separated the plasma to test the coagulation function .Result Compared with controls , after high-fat diet , the serum level of total cholesterol ( TC) , triglyceride ( TG) , high density lipoprotein ( HDL) were significantly increased , PT and APTT were shorter ( P<0.05 ).However, after treating with estradiol combined testosterone , compared with cases, the serum level of C, TG and HDL were lower and PT , APTT were longer ( P <0.05 ), had no significance with controls . Conclusion The synergistic effect of estradiol and testosterone can mediate the lipids , reduce the level of LDL , regulate the coagulation function , reduce the risk of coronary heart disease , and also provide a new strategy for hormone therapy in coronary heart disease .
