Recent Progress of DNAzyme-Nanomaterial Based Biosensors
10.11895/j.issn.0253-3820.150614
- VernacularTitle:脱氧核酶-纳米材料复合物用于生物传感研究进展
- Author:
Xuhua ZHAO
;
Hongmin MENG
;
Liang GONG
;
Liping QIU
;
Xiaobing ZHANG
;
Weihong TAN
- Publication Type:Journal Article
- Keywords:
DNAzymes;
Nanomaterials;
Biosensors;
Review
- From:
Chinese Journal of Analytical Chemistry
2015;(11):1611-1619
- CountryChina
- Language:Chinese
-
Abstract:
DNAzymes, screened through in vitro selection, were artificial nucleic acids with catalytic function . They could cleave specific substrates in the presence of cofactors with unique characteristics, such as high catalytic activity, high specificity for cofactors, excellent stability, and easy to synthesize and modify. The combination of DNAzymes with nanomaterials could retain the DNAzyme activity and realize the functional integration of recognition and signal transduction, promoting rapid development of biosensors. In the current paper, we mainly reviewed the recent progress in DNAzyme-nanomaterial based biosensors, and the nanomaterials included gold nanoparticles, graphene, quantum dots, magnetic nanomaterials, and so on.
